类风湿性关节炎患者的白细胞和淋巴细胞对滑膜细胞的细胞毒性。
The cytotoxicity of leukocytes and lymphocytes from patients with rheumatoid arthritis for synovial cells.
作者信息
Person D A, Sharp J T, Lidsky M D
出版信息
J Clin Invest. 1976 Sep;58(3):690-8. doi: 10.1172/JCI108515.
Unseparated peripheral blood leukocytes obtained from patients with rheumatoid arthritis (RA) were cytotoxic for synovial cells. The cytotoxic reactions produced by RA leukocytes were more frequent and of greater magnitude than cytotoxicity induced by leukocytes from normal persons and patients with other diseases, primarily connective tissue diseases. Furthermore, the cytotoxic activity of RA leukocytes was greater for RA synovial cells than for nonrheumatoid synovial cells, in contrast to the cytotoxicity of other leukocytes, which did not discriminate between synovial cells according to their origin. Tests with purified lymphocytes showed that the cytotoxicity of unseparated leukocytes directed against RA synovial cells was due to lymphocyte cytotoxicity. These data are consistent with the possibility that sensitized lymphocytes from patients with RA recognize a distinctive antigen present on rheumatoid synovial cells.
从类风湿性关节炎（RA）患者获得的未分离外周血白细胞对滑膜细胞具有细胞毒性。与正常人及其他疾病（主要是结缔组织疾病）患者的白细胞所诱导的细胞毒性相比，RA白细胞产生的细胞毒性反应更为频繁且程度更大。此外，与其他白细胞对滑膜细胞的细胞毒性不同，RA白细胞对RA滑膜细胞的细胞毒性比对非类风湿性滑膜细胞的细胞毒性更大，其他白细胞的细胞毒性不会根据滑膜细胞的来源进行区分。对纯化淋巴细胞的检测表明，未分离白细胞针对RA滑膜细胞的细胞毒性是由于淋巴细胞的细胞毒性所致。这些数据与RA患者致敏淋巴细胞识别类风湿滑膜细胞上存在的独特抗原这一可能性相符。
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