Naik R B, Dabek J T, Heynen G, James H M, Kanis J A, Robertson P W, Robinson B H, Woods C G
Clin Endocrinol (Oxf). 1977 Dec;7 Suppl:139s-145s. doi: 10.1111/j.1365-2265.1977.tb03374.x.
In vivo neutron activation analysis was used to measure changes in whole body calcium in patients with chronic renal failure. Eight patients, not treated by haemodialysis, showed losses of calcium in contrast to increases noted in twenty-one patients treated by haemodialysis. Changes in whole body calcium were independent of pre-existing renal bone disease. Treatment of bone disease by total parathyroidectomy (six patients) or 1alpha-hydroxyvitamin D3 (eleven patients) resulted in large increases in total body calcium. In patients given 1alpha-hydroxyvitamin D3, changes in total body calcium correlated with histological and radiological indices of response but variable changes in forearm bone mineral content were observed. Neutron activation analysis provides a convenient method for measuring skeletal mass and may also be useful in the assessment of response to 1alpha-hydroxyvitamin D3 of patients with osteitis fibrosa and osteomalacia.
采用体内中子活化分析法测定慢性肾衰竭患者全身钙含量的变化。8例未接受血液透析治疗的患者出现钙流失，而21例接受血液透析治疗的患者则出现钙增加。全身钙含量的变化与既往存在的肾性骨病无关。通过甲状旁腺全切术（6例患者）或1α-羟基维生素D3（11例患者）治疗骨病后，全身钙含量大幅增加。给予1α-羟基维生素D3的患者，全身钙含量的变化与组织学和放射学反应指标相关，但观察到前臂骨矿物质含量有不同变化。中子活化分析法为测量骨骼质量提供了一种便捷方法，也可能有助于评估纤维性骨炎和骨软化症患者对1α-羟基维生素D3的反应。
