Nielsen H E, Christensen M S, Melsen F, Rømer F K, Hansen H E
Clin Endocrinol (Oxf). 1977 Dec;7 Suppl:67s-72s. doi: 10.1111/j.1365-2265.1977.tb03364.x.
The effect of 1alpha-hydroxyvitamin D3 (1alpha-OHD3) on parathyroid function was studied in sixteen patients (ten on haemodialysis, six with chronic renal insufficiency) during treatment for 6--8 months. During treatment, a decrease in serum parathyroid hormone (s-PTH) and an increase in serum calcium were seen. An inverse linear correlation was found between serum calcium and logarithmic values of s-PTH in fifteen of sixteen patients, but the slopes of the regression lines varied considerably. This indicates that the suppression of parathyroid function seen during treatment with 1alpha-OHD3 is mediated by a rise in the serum concentration of calcium. For normalization of s-PTH, the serum concentration of calcium had to be above normal range in several patients, indicating a defect in calcium-mediated regulation of the secretion of parathyroid hormone. This abnormality was seen especially in long-term haemodialysed patients.
对16例患者（10例接受血液透析，6例患有慢性肾功能不全）进行了6至8个月的治疗，以研究1α-羟基维生素D3（1α-OHD3）对甲状旁腺功能的影响。治疗期间，血清甲状旁腺激素（s-PTH）降低，血清钙升高。16例患者中有15例血清钙与s-PTH的对数值呈负线性相关，但回归线的斜率差异很大。这表明，1α-OHD3治疗期间观察到的甲状旁腺功能抑制是由血清钙浓度升高介导的。为使s-PTH正常化，部分患者的血清钙浓度必须高于正常范围，这表明钙介导的甲状旁腺激素分泌调节存在缺陷。这种异常在长期接受血液透析的患者中尤为明显。
