产气气杆菌对戊糖醇代谢的调节。I. 核糖醇脱氢酶和D - 核糖激酶活性的协同控制。
Regulation of pentitol metabolism by Aerobacter aerogenes. I. Coordinate control of ribitol dehydrogenase and D-ribulokinase activities.
作者信息
Bisson T M, Mortlock R P
出版信息
J Bacteriol. 1968 Mar;95(3):925-31. doi: 10.1128/jb.95.3.925-931.1968.
Abstract
Induction studies on Aerobacter aerogenes strain PRL-R3, using ribitol as the inducer-substrate, indicated that two enzymes of ribitol catabolism, ribitol dehydrogenase and d-ribulokinase, are coordinately induced. The utilization of d-arabinose as a substrate resulted in the induction of ribitol dehydrogenase as well as d-ribulokinase. Mutants which were constitutive for ribitol dehydrogenase were also constitutive for d-ribulokinase. In contrast, d-xylulokinase and d-arabitol dehydrogenase did not appear to be coordinately controlled. Induction studies and examination of d-arabitol dehydrogenase constitutive mutants indicated that the three enzymes of the converging pathways for d-arabitol and d-xylose catabolism are under separate control.
摘要
以核糖醇作为诱导底物对产气气杆菌PRL-R3菌株进行的诱导研究表明，核糖醇分解代谢的两种酶，即核糖醇脱氢酶和D-核糖激酶，是协同诱导的。利用D-阿拉伯糖作为底物可诱导核糖醇脱氢酶以及D-核糖激酶。对核糖醇脱氢酶组成型的突变体对D-核糖激酶也是组成型的。相比之下，D-木酮糖激酶和D-阿拉伯糖醇脱氢酶似乎不受协同控制。诱导研究以及对D-阿拉伯糖醇脱氢酶组成型突变体的检测表明，D-阿拉伯糖醇和D-木糖分解代谢的汇聚途径中的三种酶受独立控制。
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