Sokhin A A, Lebedinskii A P, Frolov A K, Frolov V K, Sotnik A Y, Lysakova V I
J Hyg Epidemiol Microbiol Immunol. 1977;21(3):335-40.
The effect of antigenic polymorphism of the ABO-system blood groups on the character of the vaccinal process after immunization against natural smallpox was investigated. The increased susceptibility of persons possessing A antigen to the harmful effect of smallpox vaccine virus is due to hereditary rather than to acquired factors. The leukocytes of peripheral blood of these persons showed a poorer binding capacity with respect to the smallpoxvaccine virus; they also exhibited a high rate of chromosomal aberration after vaccination, resulting to some extent from increased proliferative ability of the cells.
研究了ABO血型系统抗原多态性对天然天花免疫接种后疫苗接种过程特征的影响。具有A抗原的人对天花疫苗病毒有害作用的易感性增加是由于遗传因素而非后天因素。这些人的外周血白细胞对天花疫苗病毒的结合能力较差；接种疫苗后，他们的染色体畸变率也很高，这在一定程度上是由于细胞增殖能力增强所致。
