吸烟：对人胎盘酶代谢3,4-苯并芘的刺激作用。
Cigarette smoking: stimulatory effect on metabolism of 3,4-benzpyrene by enzymes in human placenta.
作者信息
Welch R M, Harrison Y E, Conney A H, Poppers P J, Finster M
出版信息
Science. 1968 May 3;160(3827):541-2. doi: 10.1126/science.160.3827.541.
PMID:5644060
Abstract
The enzymatic hydroxylation of 3,4-benzpyrene was not detected in human placentas obtained after childbirth from nonsmokers, whereas this enzyme activity was present in placentas obtained from individuals who smoked cigarettes. The degree of induction of benzpyrene hydroxylase caused by cigarette smoking varied in different individuals. Treatment of pregnant rats with benzpyrene increased the activity of this hydroxylase in the placenta.
摘要
在分娩后从非吸烟者获得的人胎盘中未检测到3,4-苯并芘的酶促羟基化作用，而在从吸烟者获得的胎盘中存在这种酶活性。吸烟引起的苯并芘羟化酶的诱导程度在不同个体中有所不同。用苯并芘处理怀孕大鼠会增加胎盘中这种羟化酶的活性。
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