甲状腺素对促甲状腺激素[TSH]分泌调节的反馈作用。
Thyroxine feed-back on the regulation of thyrotropin [TSH] secretion.
作者信息
Panda J N, Turner C W
出版信息
J Physiol. 1968 Mar;195(1):29-37. doi: 10.1113/jphysiol.1968.sp008444.
Abstract
- The role of thyroid hormone as a feed-back at the hypothalamic level in the control of thyrotrophin (TSH) secretion and release has been investigated by estimating the plasma and pituitary TSH levels following intrahypophysial and intrahypothalamic thyroid autotransplants.2. Thyroidectomized rats bearing thyroid autotransplants in the pituitary had a significantly lower (P < 0.001) plasma TSH than that of controls at 26 degrees C but not at 4 degrees C.3. Thyroidectomized rats bearing thyroid autotransplants in the supraoptic area showed a significantly lower (P < 0.001) level of plasma TSH and higher pituitary TSH at 4 degrees C but not at 26 degrees C.4. Study with both unilaterally and bilaterally thyroidectomized rats bearing thyroid autotransplants either in the pituitary or in the hypothalamus revealed that thyroxine feed-back operates at pituitary level in normal situations (26 degrees C) and there exists a feed-back through higher centres, specifically the TSR secreting area of the hypothalamus, in situations demanding higher thyroid function, as in cold exposure.
摘要
通过评估垂体内和下丘脑内甲状腺自体移植后血浆和垂体促甲状腺激素（TSH）水平，研究了甲状腺激素在下丘脑水平对促甲状腺激素（TSH）分泌和释放的反馈作用。
在垂体中进行甲状腺自体移植的甲状腺切除大鼠，在26℃时血浆TSH水平显著低于对照组（P < 0.001），但在4℃时则不然。
在视上区进行甲状腺自体移植的甲状腺切除大鼠，在4℃时血浆TSH水平显著降低（P < 0.001），垂体TSH水平升高，但在26℃时则不然。
对单侧和双侧甲状腺切除且在垂体或下丘脑进行甲状腺自体移植的大鼠进行研究发现，甲状腺素反馈在正常情况（26℃）下在垂体水平起作用，而在需要更高甲状腺功能的情况下，如冷暴露时，存在通过更高中枢，特别是下丘脑TSR分泌区的反馈。
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