Schallert T, Whishaw I Q, Ramirez V D, Teitelbaum P
Science. 1978 Mar 31;199(4336):1461-3. doi: 10.1126/science.564552.
In otherwise profoundly akinetic rats that had been severely depleted of brain catecholamines, anticholinergic drugs caused excessive walking. The effect did not appear until 10 days after surgery and then increased with time, suggesting that a phenomenon analogous to denervation supersensitivity may be involved. If the animals walked into corners, they were unable to turn around or back out. Their gait (extremely short steps) was reminiscent of that of patients with Parkinson's disease. The results are consistent with a mutually antagonistic interaction between cholinergic and dopaminergic brain systems and emphasize certain complexities in this interaction.
在脑儿茶酚胺严重耗竭、原本极度运动不能的大鼠中，抗胆碱能药物会导致过度行走。这种效应直到手术后10天才出现，然后随时间增加，提示可能涉及一种类似于去神经超敏反应的现象。如果动物走到角落里，它们无法转身或退出。它们的步态（步幅极短）让人联想到帕金森病患者的步态。这些结果与胆碱能和多巴胺能脑系统之间相互拮抗的相互作用相一致，并强调了这种相互作用中的某些复杂性。
