Pellis S M, Pellis V C, Chesire R M, Rowland N, Teitelbaum P
Department of Psychology, University of Florida, Gainesville 32611.
Proc Natl Acad Sci U S A. 1987 Dec;84(23):8750-3. doi: 10.1073/pnas.84.23.8750.
Excessive, abnormal locomotion occurs after a high dose (25-50 mg/kg) of atropine sulfate to rats already akinetic due to catecholamine deficiency from intraventricular administration of 6-hydroxydopamine. This abnormal locomotion involves an abnormal gait sequence [right (R) hindleg (H), left (L) foreleg (F), LH, RF] instead of the normal gait sequence (RH, RF, LH, LF). In such animals atropine progressively (i) decreases hindleg step size, (ii) decreases arching of the trunk, and (iii) increases foreleg step size. These factors combine to change the ratio of front/hind body support. If the body stretches too far and the hindleg step is too small, a given hindleg step supports insufficient weight to remove weight from the ipsilateral foreleg; consequently, the opposite foreleg must execute the next step, producing the abnormal gait sequence. Thus, atropine affects gait sequence indirectly; it acts on at least three variables that affect how body weight is distributed and shifted during locomotion. To maintain stability during such locomotion, gait sequence is appropriately altered.
给因脑室内注射6-羟基多巴胺导致儿茶酚胺缺乏而已经运动不能的大鼠注射高剂量（25 - 50毫克/千克）硫酸阿托品后，会出现过度、异常的运动。这种异常运动涉及异常的步态顺序[右（R）后肢（H）、左（L）前肢（F）、左后肢、右前肢]，而不是正常的步态顺序（右后肢、右前肢、左后肢、左前肢）。在这类动物中，阿托品会逐渐（i）减小后肢步幅，（ii）减小躯干的弯曲度，以及（iii）增大前肢步幅。这些因素共同作用改变了身体前后支撑的比例。如果身体伸展得太远且后肢步幅太小，给定的后肢步幅支撑的重量不足以减轻同侧前肢的重量；因此，对侧前肢必须执行下一步，从而产生异常的步态顺序。因此，阿托品间接影响步态顺序；它作用于至少三个影响运动过程中体重分布和转移方式的变量。为了在这种运动中保持稳定性，步态顺序会相应改变。
