支气管哮喘患者的局部肺功能
Regional lung function in patients with bronchial asthma.
作者信息
Heckscher T, Bass H, Oriol A, Rose B, Anthoniesen N R, Bates D V
出版信息
J Clin Invest. 1968 May;47(5):1063-70. doi: 10.1172/JCI105796.
Abstract
The regional distribution of pulmonary ventilation and perfusion and regional alveolar ventilation/perfusion ratios were measured with radioactive xenon ((133)xenon) in 10 patients with asthma in remission. Four subjects had normal ventilation distribution, four had hypoventilation in some regions and normal ventilation in others, and two patients had abnormal ventilation in almost all lung regions. The lung bases were involved most frequently and the middle zones least frequently. Correlation was good between the degree of over-all ventilatory impairment calculated from (133)xenon values and measurement of the maximal midexpiratory flow rate the same day. Regions which were hypoventilated had low ventilation/perfusion ratios and also tended to be hypoperfused. In the eight subjects who had been studied similarly 5 yr previously, changes in regional function correlated in general with changes in over-all function.
摘要
采用放射性氙（（133）氙）对10例缓解期哮喘患者的肺通气和灌注的区域分布以及区域肺泡通气/灌注比值进行了测量。4例受试者通气分布正常，4例部分区域通气不足而其他区域通气正常，2例患者几乎所有肺区域通气均异常。肺底部受累最常见，中间区域最少见。根据（133）氙值计算出的总体通气功能损害程度与同日最大呼气中期流速测量值之间相关性良好。通气不足的区域通气/灌注比值低，且灌注也往往不足。在5年前进行过类似研究的8名受试者中，区域功能的变化总体上与总体功能的变化相关。
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