碳酸氢钠和乙酰唑胺对犬的利磷尿作用。
The phosphaturic effect of sodium bicarbonate and acetazolamide in dogs.
作者信息
Fulop M, Brazeau P
出版信息
J Clin Invest. 1968 May;47(5):983-91. doi: 10.1172/JCI105813.
Abstract
Urinary inorganic phosphate excretion was studied before and during the administration of sodium bicarbonate and acetazolamide in dogs that were not given infusions of phosphate. The excretion fraction of filtered phosphate increased after sodium bicarbonate or acetazolamide was given. This phosphaturia was attributed to decreased tubular reabsorption of phosphate consequent to alkalinization of either tubular urine or cells.
摘要
在未输注磷酸盐的犬中，研究了给予碳酸氢钠和乙酰唑胺之前及期间的尿无机磷酸盐排泄情况。给予碳酸氢钠或乙酰唑胺后，滤过磷酸盐的排泄分数增加。这种磷酸盐尿归因于肾小管尿液或细胞碱化导致的肾小管对磷酸盐重吸收减少。
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