Drobnica L, Zemanová M, Nemec P, Antos K, Kristián P, Martvon A, Závodská E
Appl Microbiol. 1968 Apr;16(4):582-7. doi: 10.1128/am.16.4.582-587.1968.
This paper presents the results of a study on the antifungal activity of isothiocyanates-derivatives of biphenyl (group "A"), of stilbene ("B"), of azobenzene and benzeneazonaphthalene ("C"), of naphthalene ("D"), and of further polycondensed aromatic hydrocarbons ("E"). From a total of 48 investigated compounds, antifungal activity was observed only in A and D group compounds. B, C, and E group derivatives are extremely insoluble in water, and the molecules are very large; as a result, they probably cannot pass into spores or mycelium of fungi. Thus, the -NCS group cannot manifest its reactivity.
本文介绍了对联苯异硫氰酸酯衍生物（“A”组）、二苯乙烯衍生物（“B”组）、偶氮苯和苯偶氮萘衍生物（“C”组）、萘衍生物（“D”组）以及其他多环芳烃衍生物（“E”组）的抗真菌活性研究结果。在总共48种被研究的化合物中，仅在“A”组和“D”组化合物中观察到抗真菌活性。“B”组、“C”组和“E”组衍生物极难溶于水，且分子非常大；因此，它们可能无法进入真菌的孢子或菌丝体。这样一来，-NCS基团就无法表现出其反应活性。
