Bemrick W J, O'Leary T P, Averbeck G A
Immunology. 1977 Apr;32(4):567-72.
A homocytotropic anaphylactic response is described in guinea-pigs sensitized with antigen from Parascaris equorum. This antigen was not sensitive to prolonged storage in formalin. Some adult ascarid extracts prepared from worms that had been stored for 14 years in 10 per cent formalin before use, retained their ability to produce an allergenic response. The antisera withstood heat inactivation at 56 degrees for up to 7 h or treatment with 2-mercaptoethanol and were still capable of eliciting a skin response. The skin response persisted for 96 h after sensitization. The serum of animals sensitized with a single dose of P. equorum antigen remained capable of producing a positive passive cutaneous anaphylactic response up to 245 days after the sensitizing dose. It appears, from the results obtained, that this antibody resembles IgG1, rather than IgE.
在用马副蛔虫抗原致敏的豚鼠中描述了一种亲同种细胞的过敏反应。这种抗原对在福尔马林中长时间储存不敏感。一些从在使用前已在10%福尔马林中储存14年的蠕虫制备的成虫蛔虫提取物，仍保留产生过敏反应的能力。抗血清在56℃下可耐受长达7小时的热灭活或用2-巯基乙醇处理，并且仍能够引发皮肤反应。致敏后皮肤反应持续96小时。用单剂量马副蛔虫抗原致敏的动物血清在致敏剂量后长达245天仍能够产生阳性被动皮肤过敏反应。从获得的结果来看，这种抗体似乎类似于IgG1，而不是IgE。
