小鼠IgG和IgE亲同种细胞抗体在被动皮肤过敏反应中的作用。
Role of mouse IgG and IgE homocytotropic antibodies in passive cutaneous anaphylaxis.
作者信息
Lehrer S B
出版信息
Immunology. 1977 Apr;32(4):507-11.
The role of the mouse homocytotropic antibodies in passive cutaneous anaphylaxis reaction was investigated. One class of antibody was heat stable, detected at 2 h but not at 48 h after passive transfer, and belonged to a sublcass of mouse IgG. The other was heat labile, detected at 2 h and 48 h after passive transfer, and belonged to the IgE class of mouse immunoglobulins. In the presence of IgG, IgE homocytotropic antibody was not detected early after passive transfer. This was thought to be due to a masking of IgE by IgG antibodies rather than a competition for mast cell surface receptors, since inhibition studies with rat IgE myeloma protein suggested that mouse IgE and IgG1 may have different receptor sites on mast cell surfaces.
研究了小鼠亲同种细胞抗体在被动皮肤过敏反应中的作用。一类抗体耐热，在被动转移后2小时可检测到，但在48小时后检测不到，属于小鼠IgG的一个亚类。另一类抗体不耐热，在被动转移后2小时和48小时均可检测到，属于小鼠免疫球蛋白的IgE类。在存在IgG的情况下，被动转移后早期未检测到IgE亲同种细胞抗体。这被认为是由于IgG抗体掩盖了IgE，而不是对肥大细胞表面受体的竞争，因为用大鼠IgE骨髓瘤蛋白进行的抑制研究表明，小鼠IgE和IgG1在肥大细胞表面可能有不同的受体位点。
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