Streja D, Corenbium B, Ezrin C
JAMA. 1978 Apr 28;239(17):1783-5.
A young woman with secondary amenorrhea was also found to have a deficiency of growth hormone. Functional deficiency of adrenocorticotropic and thyroid stimulating hormones, and probably prolactin-inhibiting hormone, developed subsequently. No evidence of a mass lesion in the hypothalamic pituitary axis was found. She failed to respond to any pharmacologic agent believed to act functionally at a suprapituitary level, but responded to all stimuli believed to act directly on the pituitary. This progressive failure of the endocrine hypothalamus may be an extension of the idiopathic hypopituitarism syndrome found in children.
一名继发性闭经的年轻女性还被发现生长激素缺乏。随后出现促肾上腺皮质激素和促甲状腺激素功能不足，可能还有催乳素抑制激素功能不足。下丘脑 - 垂体轴未发现占位性病变迹象。她对任何据信在垂体上水平起作用的药物均无反应，但对所有据信直接作用于垂体的刺激有反应。这种内分泌下丘脑的进行性功能衰竭可能是儿童特发性垂体功能减退综合征的一种延伸。
