Colodny A H, Hopkins T B
Urol Clin North Am. 1977 Oct;4(3):347-58.
Forty three children with testicular tumors have been presented. Eighty per cent of these tumors were malignant, and 60 per cent occurred in children less than two and one half years of age. Twenty of the 24 malignant germinal tumors were embryonal cell carcinomas. The mean age of the patients at presentation of these tumors was 18 months. Nine patients underwent orchiectomy alone, and five of these have died. Eleven received combined therapy, and all have survived. We currently recommend radical orchiectomy and extended unilateral retroperitoneal lymphadenectomy. If examination of the nodes reveals evidence of metastases, a bilateral dissection is done. Radiotherapy is given only in the presence of nodal metastases. Adjuvant chemotherapy with vincristine, actinomycin D, and Cytoxan is given for two years to all patients with malginant nonseminomatous germ cell tumors or sarcomas.
本文报告了43例睾丸肿瘤患儿。其中80%的肿瘤为恶性，60%发生在2岁半以下的儿童。24例恶性生殖细胞肿瘤中有20例为胚胎细胞癌。这些肿瘤患者就诊时的平均年龄为18个月。9例患者仅接受了睾丸切除术，其中5例已死亡。11例接受了联合治疗，均存活。我们目前建议行根治性睾丸切除术和扩大的单侧腹膜后淋巴结清扫术。如果淋巴结检查显示有转移迹象，则进行双侧清扫。仅在有淋巴结转移时给予放疗。对于所有恶性非精原细胞性生殖细胞肿瘤或肉瘤患者，给予长春新碱、放线菌素D和环磷酰胺辅助化疗两年。
