Ablin R J, Bush I M, Bruns G R, John T, Sadoughi N, Guinan P D
Urology. 1978 Mar;11(3):289-92. doi: 10.1016/0090-4295(78)90139-5.
In an attempt to evaluate the degree of in vitro cellular sensitization to tumor and its relationship to clinical responsiveness, direct leukocyte migration tests were carried out in patients with varying degrees of adenocarcinoma of the prostate employing pooled allogeneic extracts of normal, benign, and malignant prostatic tissue as a source of antigen. Cell-mediated immunity to presumably common prostatic tumor associated antigens was observed. The degree of sensitization of clinically significant specific reactivity of the patients' leukocytes to malignant prostatic tissue was greatest in patients with localized disease, low-grade tumor, and clinically inactive disease than in patients with advanced disease, high-grade tumor, and clinically active disease. Evaluation of the possible correlation of specific reactivity to malignant prostatic tissue as a prognostic index of clinical responsiveness revealed a positive correlation with the degree of sensitization in 3 (43 per cent) of 7 patients. Correlation in 4 patients was questionable because of observations of "stimulation" of migration rather than inhibition, suggested by some to be reflective of weak sensitization to tumor. Evaluation of a larger patient population as well as a prospective study of the relationship of the degree of sensitization and clinical responsiveness will be necessary before any definitive conclusions may be drawn regarding the present observations.
为了评估体外细胞对肿瘤的致敏程度及其与临床反应性的关系，我们使用正常、良性和恶性前列腺组织的混合同种异体提取物作为抗原来源，对不同程度前列腺腺癌患者进行了直接白细胞迁移试验。观察到对推测的常见前列腺肿瘤相关抗原的细胞介导免疫。与患有晚期疾病、高级别肿瘤和临床活跃疾病的患者相比，患有局限性疾病、低级别肿瘤和临床不活跃疾病的患者白细胞对恶性前列腺组织的临床显著特异性反应的致敏程度更高。将对恶性前列腺组织的特异性反应作为临床反应性的预后指标进行相关性评估，结果显示7例患者中有3例（43%）的致敏程度呈正相关。4例患者的相关性存在疑问，因为观察到迁移是“刺激”而非抑制，有人认为这反映了对肿瘤的弱致敏。在就目前的观察结果得出任何明确结论之前，有必要评估更多的患者群体，并对致敏程度与临床反应性的关系进行前瞻性研究。
