Ablin R J, Bhatti R A, Bush I M, Guinan P D
J Reprod Immunol. 1980 Feb;1(5-6):337-45. doi: 10.1016/0165-0378(80)90007-8.
Tumour-associated antigen-induced leukocyte adherence inhibition has been used as an in vitro criterion for evaluating the effect of normal human seminal plasma (HuSePl) on cell-mediated anti-tumour-associated immunity in patients with adenocarcinoma of the prostate. Significant (P < 0.01) suppression from the reactivity obtained with unincubated patients' leukocytes to allogenic extracts of malignant prostatic tissue ranging from 16 to 80% was observed in 22 of 25 patients (88%) following preincubation of their leukocytes with HuSePl. The observed suppression of tumour-associated immunity in the presence of HuSePl provides further evidence for the suppressive activity of SePl on a range of in vitro immune response in normal murine and human hosts. It is suggested that these results, together with those demonstrating experimental prostatic cancer from sensitization by spermatozoa and the relationship of prostatic cancer to repression of sexual activity, provide preliminary evidence of the possible participation of SePl as contributory to the natural history of prostatic cancer.
肿瘤相关抗原诱导的白细胞黏附抑制已被用作一种体外标准，用于评估正常人精浆（HuSePl）对前列腺腺癌患者细胞介导的抗肿瘤相关免疫的影响。在25例患者中的22例（88%）中，其白细胞与HuSePl预孵育后，观察到从未孵育患者白细胞对恶性前列腺组织同种异体提取物获得的反应性有显著（P < 0.01）抑制，抑制范围为16%至80%。在HuSePl存在下观察到的肿瘤相关免疫抑制为SePl对正常小鼠和人类宿主一系列体外免疫反应的抑制活性提供了进一步证据。有人提出，这些结果，连同那些证明精子致敏导致实验性前列腺癌以及前列腺癌与性活动抑制之间关系的结果，为SePl可能参与前列腺癌自然史提供了初步证据。
