Davajan V, Kletzky O, March C M, Roy S, Mishell D R
Am J Obstet Gynecol. 1978 Apr 15;130(8):894-904. doi: 10.1016/0002-9378(78)90266-1.
Thyroid-stimulating hormone and prolactin (PRL) were measured in a group of 149 women with galactorrhea. Three of these patients were found to have primary hypothyroidism. In the remaining 146 patients, the PRL assay was correlated with the menstrual history and the results of hypocycloidal polytomography. Sixty-two per cent of these patients had hyperprolactinemia and 35 per cent had abnormal tomograms. Nine patients with abnormal x-rays had normal prolactin levels. None of the patients with normal menses and normal PRL was found to have an abnormal x-ray. Fourteen of the 15 patients with PRL levels greater than 200 ng. per milliliter had abnormal tomograms. Almost 70 per cent of patients with secondary amenorrhea and low estrogen status had abnormal x-rays. In patients with oligomenorrhea and secondary amenorrhea with normal estrogen status, it was not possible to differentiate between patients with normal or abnormal tomograms based on the level of serum PRL. Polytomography remains the single most important diagnostic test in establishing the presence of a pituitary tumor.
对149例溢乳女性进行了促甲状腺激素和催乳素（PRL）检测。其中3例患者被发现患有原发性甲状腺功能减退症。在其余146例患者中，PRL检测结果与月经史及蝶鞍断层扫描结果相关。这些患者中62%患有高催乳素血症，35%的蝶鞍断层扫描结果异常。9例X线检查异常的患者催乳素水平正常。月经和PRL水平正常的患者均未发现X线检查异常。PRL水平高于200 ng/毫升的15例患者中有14例蝶鞍断层扫描结果异常。几乎70%继发性闭经且雌激素水平低的患者X线检查异常。在月经稀发和继发性闭经且雌激素水平正常的患者中，无法根据血清PRL水平区分蝶鞍断层扫描结果正常或异常的患者。蝶鞍断层扫描仍然是诊断垂体肿瘤最重要的单项检查。
