非糖尿病患者前臂肌肉中内源性血清胰岛素浓度与葡萄糖摄取之间的关系。
The relationship between endogenous serum insulin concentration and glucose uptake in the forearm muscles of nondiabetics.
作者信息
Christensen N J, Orskov H
出版信息
J Clin Invest. 1968 Jun;47(6):1262-8. doi: 10.1172/JCI105818.
Abstract
IN A SERIES OF EXPERIMENTS ON THE HUMAN FOREARM, PREPARATION DESIGNED TO EXAMINE THE EFFECTS OF VARIATIONS IN IMMUNOLOGICALLY DETERMINED ENDOGENOUS SERUM INSULIN LEVELS AND OF BLOOD GLUCOSE CONCENTRATIONS ON MUSCULAR GLUCOSE UPTAKE, THE FOLLOWING RESULTS WERE OBTAINED: (a) A highly significant correlation between muscular glucose uptake and simultaneous arterial serum insulin concentration. (b) No correlation between glucose uptake and simultaneous arterial blood glucose concentration during hyperglycemia. (c) A maximal insulin effect on muscular glucose uptake at arterial serum insulin concentrations at about 200 muU/ml. This observation is, however, based on only a few experiments.
摘要
在一系列针对人体前臂的实验中，实验准备旨在研究免疫测定的内源性血清胰岛素水平变化以及血糖浓度对肌肉葡萄糖摄取的影响，得到了以下结果：(a) 肌肉葡萄糖摄取与同时的动脉血清胰岛素浓度之间存在高度显著的相关性。(b) 在高血糖期间，葡萄糖摄取与同时的动脉血糖浓度之间无相关性。(c) 当动脉血清胰岛素浓度约为200微单位/毫升时，胰岛素对肌肉葡萄糖摄取有最大效应。然而，这一观察结果仅基于少数实验。
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