Page M M, Alberti K G, Greenwood R, Gumaa K A, Hockaday T D, Lowy C, Nabarro J D, Pyke D A, Sönksen P H, Watkins P J, West T E
Br Med J. 1974 Jun 29;2(5921):687-90. doi: 10.1136/bmj.2.5921.687.
Thirty-eight patients in diabetic coma from four different centres were treated with a continuous low-dose intravenous infusion of insulin at an average dose of 7.2 IU/hr. All patients recovered rapidly except for one profoundly shocked patient who died. The mean fall in plasma glucose was 58% four hours after the start of insulin. Blood ketone bodies and plasma free fatty acids showed a similar response. There was no significant difference in plasma glucose response according to severity of acidosis or previous treatment with insulin. Hypokalaemia was uncommon. In the treatment of diabetic coma this technique has proved simple, safe, and effective.
来自四个不同中心的38例糖尿病昏迷患者接受了平均剂量为7.2 IU/小时的胰岛素持续低剂量静脉输注治疗。除一名严重休克患者死亡外，所有患者均迅速康复。胰岛素开始输注4小时后，血浆葡萄糖平均下降58%。血酮体和血浆游离脂肪酸表现出类似反应。根据酸中毒严重程度或既往胰岛素治疗情况，血浆葡萄糖反应无显著差异。低钾血症并不常见。在糖尿病昏迷的治疗中，该技术已被证明简单、安全且有效。
