DeMeglio D C, Friedman T B
J Biochem. 1978 Mar;83(3):693-8. doi: 10.1093/oxfordjournals.jbchem.a131962.
Dictyostelium discoideum is able to metabolize [1-14C]galactose to 14CO2 despite the observation that galactose is inhibitory with respect to growth. Galactose-1-phosphate uridyl transferase activity is present throughout growth and development and varies in activity only slightly during the entire life cycle of D. discoideum, in contrast to the rapid increase in UDP-glucose 4-epimerase activity during development. Therefore, in D. discoideum, these two enzymes of the Leloir pathway are independently regulated, unlike E. coli where these enzymes are coordinately controlled.
尽管观察到半乳糖对盘基网柄菌的生长具有抑制作用，但它仍能够将[1-¹⁴C]半乳糖代谢为¹⁴CO₂。1-磷酸半乳糖尿苷酰转移酶的活性在整个生长和发育过程中都存在，并且在盘基网柄菌的整个生命周期中活性仅有轻微变化，这与发育过程中UDP-葡萄糖4-差向异构酶活性的快速增加形成对比。因此，在盘基网柄菌中，Leloir途径的这两种酶是独立调节的，这与大肠杆菌中这些酶受到协同控制不同。
