紫外线照射的DNA中胸腺嘧啶的光二聚体：通过X射线衍射确定结构
Photodimer of thymine in ultraviolet-irradiated DNA: proof of structure by x-ray diffraction.
作者信息
Camerman N, Camerman A
出版信息
Science. 1968 Jun 28;160(3835):1451-2. doi: 10.1126/science.160.3835.1451.
PMID:5654055
Abstract
Dimethylthymine was photodimerized with ultraviolet radiation, and the structure of one of the resulting dimers, the cis 5,5 : 6,6 isomer, was determined by single-crystal x-ray diffraction. This isomer is the same as that obtained by ultraviolet irradiation of DNA; hence the structure of the thymine dimer in irradiated DNA is now proved.
摘要
二甲基胸腺嘧啶经紫外线辐射发生光二聚化反应，通过单晶X射线衍射确定了其中一种生成的二聚体——顺式5,5 : 6,6异构体的结构。该异构体与DNA经紫外线照射后得到的异构体相同；因此，现已证实了受辐照DNA中胸腺嘧啶二聚体的结构。
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