Reinken L, Kurz R
Klin Padiatr. 1978 Mar;190(2):163-7.
The effect of combined iron-vitamin therapy and iron therapy only was studied in 14 respectively 14 children with hypochromic anemia. Pyridoxalphosphate in serum, activity of red cell glutamic oxaloacetic transaminase and excretion of 4-pyridoxic acid were measured as indices of vitamin B6 nutriture before therapy was started, four and seven days under therapy once more. Erythrocytes, reticulocytes, concentration of hemoglobin were simultaneously counted, whereas serum iron and transferrin have been measured before and after therapy. A group of 22 hematologically healthy children was studied as controls. After iron therapy a decrease of vitamin B6 body pool came off as a consequence of increased requirement of pyridoxalphosphate for heme synthesis. Additional dosage of vitamins compensated the biochemical B6 deficit and had an accelerating effect on heme synthesis.
分别对14名患低色素性贫血的儿童进行了铁 - 维生素联合疗法和单纯铁疗法的效果研究。在开始治疗前、治疗4天和7天后，分别测定血清中的磷酸吡哆醛、红细胞谷草转氨酶活性以及4 - 吡哆酸的排泄量，以此作为维生素B6营养状况的指标。同时对红细胞、网织红细胞、血红蛋白浓度进行计数，并在治疗前后测定血清铁和转铁蛋白。选取22名血液学健康儿童作为对照组进行研究。铁疗法后，由于血红素合成对磷酸吡哆醛的需求增加，导致维生素B6体内储备减少。额外补充维生素可弥补生化方面的B6缺乏，并对血红素合成有促进作用。
