锂对小龙虾牵张感受器神经元不同膜成分的影响。
Effects of lithium on different membrane components of crayfish stretch receptor neurons.
作者信息
Obara S, Grundfest H
出版信息
J Gen Physiol. 1968 May;51(5):635-54. doi: 10.1085/jgp.51.5.635.
Abstract
Unlike several other varieties of input membrane, that of the crayfish stretch receptor develops a generator potential in response to stretch when all the Na of the medium is replaced with Li. However, Li depolarizes the receptor neuron, the soma membrane becoming more depolarized than that of the axon. During exposure to Li the cell usually fires spontaneously for a period, and when it becomes quiescent spike electrogenesis fails in the soma but persists in the axon. These effects are seen in the rapidly adapting as well as the slowly adapting cells. The block of spike electrogenesis of the soma membrane is only partly due to the Li-induced depolarization and a significant role must be ascribed to a specific effect of Li.
摘要
与其他几种输入膜不同，当培养基中的所有钠都被锂取代时，小龙虾牵张感受器的膜会因牵张而产生发生器电位。然而，锂会使感受器神经元去极化，细胞体膜的去极化程度比轴突膜更高。在暴露于锂的过程中，细胞通常会自发放电一段时间，当它变得静止时，体细胞的锋电位电发生会失败，但在轴突中仍会持续。在快速适应细胞和缓慢适应细胞中都能看到这些效应。体细胞膜锋电位电发生的阻断仅部分归因于锂诱导的去极化，锂的特定作用必须被赋予重要角色。
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