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从百脉根内生真菌中分离得到的差向异构1-(3-吲哚基)丙烷-1,2,3-三醇的测定

Determination of epimeric 1-(3-indolyl) propane -1,2,3-triol isolated from Balansia epichloe.

作者信息

Porter J K, Robbins J D, Bacon C W, Himmelsbach D S, Haeberer A F

出版信息

Lloydia. 1978 Jan-Feb;41(1):43-9.

PMID:565455
Abstract

Investigations into diseases in cattle grazing on grass pastures infected with clavicipitaceous fungi have resulted in the isolation and characterization of erythro and threo 1-(3-indolyl) propane-1,2,3-triol from cultures of Balansia epichloë (Weese). Gas chromatography-mass spectroscopy analyses of synthetic and natural epimers as their trimethylsilyl derivatives is described. Toxicity studies with fertile chicken eggs demonstrated that the threo epimer was the more active compound. The ratio of erythro to threo was calculated at 3:2 in the natural isolate.

摘要

对在感染了麦角菌科真菌的草地上放牧的牛所患疾病进行的调查,已从布氏麦角菌(Weese)培养物中分离并鉴定出赤藓型和苏阿糖型1-(3-吲哚基)丙烷-1,2,3-三醇。描述了对合成和天然差向异构体作为其三甲基硅烷基衍生物的气相色谱-质谱分析。用可育鸡蛋进行的毒性研究表明,苏阿糖型差向异构体是活性更强的化合物。天然分离物中赤藓型与苏阿糖型的比例经计算为3:2。

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