Rodnitzky R L, Kimura J
Neurology. 1978 May;28(5):431-3. doi: 10.1212/wnl.28.5.431.
In 76 patients with multiple sclerosis, the blink reflex was elicted electrically at normal body temperature and during induced hyperthermia to observe the effect on conduction within the reflex pathway through the brainstem. Special attention was directed to 31 patients with electrophysiologic evidence of reflex slowing, presumably because of demyelination in the reflex pathway. Hyperthermia did not induce any significant changes in mean reflex latency, amplitude, or duration in either the overall group of 76 or in the 31 patients with baseline blink reflex abnormalities. While the mean reflex latency did not change, 13 (33 percent) of 39 abnormal R1 responses from the 31 patients changed by 1.5 msec or more during hyperthermia, whereas change of similar magnitude was noted in only three (3 percent) of 90 normal R1 responses.
对76例多发性硬化症患者，在正常体温及诱导性体温过高期间进行电刺激诱发眨眼反射，以观察对通过脑干的反射通路内传导的影响。特别关注31例有反射减慢电生理证据的患者，推测是由于反射通路脱髓鞘所致。体温过高在76例患者的总体组或31例基线眨眼反射异常的患者中，均未引起平均反射潜伏期、波幅或时限的任何显著变化。虽然平均反射潜伏期未改变，但31例患者中39个异常R1反应中的13个（33%）在体温过高期间变化了1.5毫秒或更多，而90个正常R1反应中只有3个（3%）出现了类似幅度的变化。
