Unanue E R, Askonas B A
J Exp Med. 1968 May 1;127(5):915-26. doi: 10.1084/jem.127.5.915.
Peritoneal macrophages were cultured for several hours after uptake of (131)I-hemocyanin. The cells degraded most of the (131)I-labeled protein within 2-5 hr. Their ability to prime lymphocytes of syngeneic mice for a secondary immune challenge remained unchanged for long periods of time despite the loss of more than 90% of the original content of antigen. The persistence of immunogenicity was associated with a small percentage of antigen retained by the cell in a form which was protected from rapid breakdown and elimination.
摄取（131）I - 血蓝蛋白后，腹膜巨噬细胞培养数小时。细胞在2 - 5小时内降解了大部分（131）I标记的蛋白质。尽管超过90%的原始抗原含量丧失，但它们激发同基因小鼠淋巴细胞进行二次免疫攻击的能力在很长一段时间内保持不变。免疫原性的持续存在与细胞以一种免受快速分解和清除的形式保留的一小部分抗原有关。
