Klippel K F, Wenderoth U
Res Exp Med (Berl). 1978 Mar 20;172(2):173-9. doi: 10.1007/BF01851408.
In an experimental study in rabbits, histoxicity of butyl-2-cyano-acrylic-tissue adhesive for orchiopexy was comapred with the usual suture type fixation of the testis. There was no difference in tissue damage between the two methods in respect to local inflammation, diameters of the tubules and the number of spermatogonic cells. Using several established cell lines, a significant cytotoxicity was seen when dropping butyl-2-cyanoacrylic-adhesive into the tissue cultures. Mutagenic influence of butyl-2-cyanoacrylate should be ruled out in children prior to clinical application. In addition, the high cost of the adhesive should be considered.
在一项对兔子的实验研究中，将用于睾丸固定术的丁基-2-氰基丙烯酸组织粘合剂的组织毒性与常用的睾丸缝合固定方法进行了比较。在局部炎症、小管直径和精原细胞数量方面，两种方法在组织损伤上没有差异。使用几种已建立的细胞系，当将丁基-2-氰基丙烯酸粘合剂滴入组织培养物中时，观察到显著的细胞毒性。在临床应用前，应排除丁基-2-氰基丙烯酸酯对儿童的致突变影响。此外，还应考虑粘合剂的高成本。
