Nemeroff C B, Osbahr A J, Bissette G, Jahnke G, Lipton M A, Prange A J
Science. 1978 May 19;200(4343):793-4. doi: 10.1126/science.565535.
Peripheral administration of the COOH-terminal octapeptide of cholecystokinin in doses from 1 to 100 micrograms per kilogram of body weight (0.25 to 25.0 micrograms per rat) significantly antagonized tail pinch-induced eating in rats, an animal model for stress-induced human hyperphagia. Centrally administered cholecystokinin was effective only in high doses (3 micrograms into the cerebral ventricle). The finding that the minimal effective dose of cholecystokinin in suppressing stress-induced appetitive behavior is smaller after peripheral than central administration suggests that the peptide is acting on peripheral, as opposed to central nervous system, substrates.
以每千克体重1至100微克（每只大鼠0.25至25.0微克）的剂量对外周给予胆囊收缩素的羧基末端八肽，可显著对抗大鼠的夹尾诱导进食行为，这是一种应激诱导的人类食欲亢进的动物模型。中枢给予胆囊收缩素仅在高剂量时（向脑室注射3微克）有效。胆囊收缩素在外周给药后抑制应激诱导的摄食行为的最小有效剂量比中枢给药时小，这一发现表明该肽作用于外周而非中枢神经系统底物。
