头孢菌素生物合成中β-内酰胺形成的立体化学。
The stereochemistry of beta-lactam formation in cephalosporin biosynthesis.
作者信息
Huddleston J A, Abraham E P
出版信息
Biochem J. 1978 Mar 1;169(3):705-7. doi: 10.1042/bj1690705.
Abstract
3H and 14C from (2R,3S)[U-14C,3-3H1]cysteine and (2R,3R)-[U-14C,2,3-3H2]cysteine were incorporated into cephalosporin C by Cephalosporium acremonium. Analysis of the radioactive cephalosporin C indicated that the formation of its beta-lactam ring occurs stereospecifically and with retention of configuration at C-3 of cysteine.
摘要
顶头孢霉将（2R，3S）-[U-¹⁴C，3-³H₁]半胱氨酸和（2R，3R）-[U-¹⁴C，2，3-³H₂]半胱氨酸中的³H和¹⁴C掺入头孢菌素C中。对放射性头孢菌素C的分析表明，其β-内酰胺环的形成具有立体特异性，且半胱氨酸C-3位的构型得以保留。
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本文引用的文献
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Biosynthesis of cephalosporin C from amino acids.由氨基酸合成头孢菌素C。
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The structure of cephalesporin C.头孢菌素C的结构。
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Studies on the biosynthesis of beta-lactam antibiotics. Part II. Synthesis, and incorporation into penicillin G, of (2'RS, 3'R)-(3,3'-3H2)-cystine and (2RS, 2'RS, 3S, 3'S)-(3,3'-3H2) cystine.β-内酰胺抗生素的生物合成研究。第二部分。（2'RS，3'R）-（3,3'-3H₂）-胱氨酸和（2RS，2'RS，3S，3'S）-（3,3'-3H₂）胱氨酸的合成及其掺入青霉素G的研究。
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5
The stereochemistry of beta-lactam formation in penicillin biosynthesis.青霉素生物合成中β-内酰胺形成的立体化学
Eur J Biochem. 1977 May 2;75(1):133-47. doi: 10.1111/j.1432-1033.1977.tb11511.x.
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