关于α-胰凝乳蛋白酶催化酰苯胺水解酰化步骤的作用机制 - Suppr

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On the mechanism of action at the acylation step of the alpha-chymotrypsin-catalyzed hydrolysis of anilides.

作者信息

Parker L, Wang J H

出版信息

J Biol Chem. 1968 Jul 10;243(13):3729-34.

PMID:5658548

Abstract

摘要

相似文献

On the mechanism of action at the acylation step of the alpha-chymotrypsin-catalyzed hydrolysis of anilides.关于α-胰凝乳蛋白酶催化酰苯胺水解酰化步骤的作用机制

J Biol Chem. 1968 Jul 10;243(13):3729-34.

Chymotrypsin-catalyzed hydrolysis of m-, p-, and o-nitroanilides of N-benzoyl-L-tyrosine.胰凝乳蛋白酶催化的N-苯甲酰基-L-酪氨酸的间硝基苯胺、对硝基苯胺和邻硝基苯胺的水解反应。

Biochemistry. 1966 Feb;5(2):808-11. doi: 10.1021/bi00866a056.

The application of insolubilized alpha-chymotrypsin to kinetic studies on the effect of aprotic dipolar organic solvents.不溶性α-糜蛋白酶在非质子偶极有机溶剂作用的动力学研究中的应用。

J Biol Chem. 1974 Apr 10;249(7):2130-4.

Mechanism of chymotrypsin. Structure, reactivity, and nonproductive binding relationships.胰凝乳蛋白酶的作用机制。结构、反应活性及非生产性结合关系。

Biochemistry. 1973 Mar 13;12(6):1067-74. doi: 10.1021/bi00730a008.

CHYMOTRYPSIN-CATALYZED HYDROLYSIS OF N-ACETYL- AND N-BENZOYL-L-TYROSINE P-NITROANILIDES.胰凝乳蛋白酶催化的N-乙酰基和N-苯甲酰基-L-酪氨酸对硝基苯胺的水解反应

Arch Biochem Biophys. 1963 Sep;102:416-22. doi: 10.1016/0003-9861(63)90249-2.

Demonstration of the acyl-enzyme mechanism for the hydrolysis of peptides and anilides by chymotrypsin.糜蛋白酶催化肽和酰苯胺水解的酰基-酶机制的证明。

Biochemistry. 1973 May 22;12(11):2025-34. doi: 10.1021/bi00735a001.

An electrophilic mechanism in the chymotrypsin-catalyzed hydrolysis of anilide substrates.胰凝乳蛋白酶催化酰苯胺底物水解的亲电机制。

J Am Chem Soc. 1965 Jan 5;87(1):126-7. doi: 10.1021/ja01079a027.

Chymotrypsin catalysis. Evidence for a new intermediate.

J Am Chem Soc. 1972 Feb 9;94(3):960-3. doi: 10.1021/ja00758a039.

Kinetics of the alpha-chymotrypsin-catalyzed hydrolysis of N-ACETYL-L-phenylalanylglycine amide in the equilibrium state: profit of an acylenzyme mechanism.α-胰凝乳蛋白酶催化N-乙酰-L-苯丙氨酰甘氨酸酰胺在平衡状态下水解的动力学：酰基酶机制的作用

Mol Biol. 1974 May;7(6):667-72.

Separation of polar, steric and specific effects in the alpha-chymotrypsin-catalyzed hydrolysis of acyl-substituted p-nitrophenyl esters.α-胰凝乳蛋白酶催化酰基取代对硝基苯酯水解过程中极性、空间效应和特异性效应的分离

Biochem Biophys Res Commun. 1970 Oct 23;41(2):464-70. doi: 10.1016/0006-291x(70)90528-0.

引用本文的文献

Kinetic Studies of the Effect of pH on the Trypsin-Catalyzed Hydrolysis of -α-benzyloxycarbonyl-l-lysine--nitroanilide: Mechanism of Trypsin Catalysis.pH对胰蛋白酶催化水解α-苄氧羰基-L-赖氨酸-对硝基苯胺影响的动力学研究：胰蛋白酶催化机制

ACS Omega. 2020 Mar 3;5(10):4915-4923. doi: 10.1021/acsomega.9b03750. eCollection 2020 Mar 17.

Influence of Leaving-Group Electronic Effect on alpha-Chymotrypsin: Catalytic Constants of Specific Substrates.离去基团电子效应对α-胰凝乳蛋白酶的影响：特定底物的催化常数

Proc Natl Acad Sci U S A. 1973 Feb;70(2):517-20. doi: 10.1073/pnas.70.2.517.

Active Site of alpha-Chymotrypsin Activation by Association-Desolvation.通过缔合去溶剂化激活α-糜蛋白酶的活性位点

Proc Natl Acad Sci U S A. 1970 Jun;66(2):249-56. doi: 10.1073/pnas.66.2.249.

Kinetics of subtilisin and thiolsubtilisin.枯草杆菌蛋白酶和巯基枯草杆菌蛋白酶的动力学

Mol Cell Biochem. 1983;51(1):5-32. doi: 10.1007/BF00215583.

The nature of general base-general acid catalysis in serine proteases.

Proc Natl Acad Sci U S A. 1969 Dec;64(4):1335-42. doi: 10.1073/pnas.64.4.1335.

pH-dependence and structure-activity relationships in the papain-catalysed hydrolysis of anilides.木瓜蛋白酶催化酰苯胺水解反应中的pH依赖性及构效关系

Biochem J. 1971 Aug;124(1):117-22. doi: 10.1042/bj1240117.

Directional character of proton transfer in enzyme catalysis.酶催化中质子转移的方向性特征。

Proc Natl Acad Sci U S A. 1970 Jul;66(3):874-81. doi: 10.1073/pnas.66.3.874.

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