人体甲状旁腺激素尿排泄的研究。
A study of urinary excretion of parathyroid hormone in man.
作者信息
Bethune J E, Turpin R A
出版信息
J Clin Invest. 1968 Jul;47(7):1583-9. doi: 10.1172/JCI105850.
A procedure for bioassaying parathyroid hormone-like activity in human urine has been developed. 24-hr urine samples were concentrated with dry Sephadex G-25 and bioassayed in the young thyroparathyrocauterized mouse by the measurement of whole blood calcium. Recovery of biological activity and radioiodinated beef parathyroid hormone was over 80%. Normal subjects usually excreted less than 30 U (USP) of activity per day while 18 patients with proven primary hyperparathyroidism excreted a mean of 182 U/day (USP). The activity was not found in 7 patients with hypoparathyroidism or in 5 patients with carcinoma of the breast, but was present in 9 patients with uremia and in 5 with carcinoma of the lung and hypercalcemia.
已开发出一种用于生物测定人尿中甲状旁腺激素样活性的方法。24小时尿液样本用干燥的葡聚糖凝胶G - 25浓缩，并通过测量全血钙在年轻的甲状腺甲状旁腺切除小鼠中进行生物测定。生物活性和放射性碘化牛甲状旁腺激素的回收率超过80%。正常受试者通常每天排泄的活性低于30 U（美国药典单位），而18例经证实的原发性甲状旁腺功能亢进患者平均每天排泄182 U（美国药典单位）。7例甲状旁腺功能减退患者和5例乳腺癌患者未发现该活性，但9例尿毒症患者以及5例肺癌伴高钙血症患者中存在该活性。
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