尿液中的甲状旁腺激素样生物活性。

Parathyroid hormone-like biological activity in urine.

Nijs-De Wolf N, De Nutte N, Brauman H, Corvilain J

Clin Sci Mol Med. 1978 Apr;54(4):349-53. doi: 10.1042/cs0540349.

Abstract

The parathyroid hormone-like biological activity of concentrated urine was measured by the increase of plasma calcium concentration after intravenous injection of the sample into chickens. 2. Urine was tested in hypoparathyroid patients, normal volunteer subjects, primary hyperparathyroid patients before and after surgery and patients with secondary hyperparathyroidism. 3. In primary and secondary hyperparathyroidism the biological activity was significantly higher than in urine from normal subjects, which was in turn significantly higher than the activity in the urine of hypoparathyroid patients. This bioactivity diminished after surgical removal of a hyperparathyroid adenoma. 4. Decreased activity after trypsinization indicated the peptidic nature of the hypercalcaemic substance.

摘要

通过将浓缩尿液样本静脉注射到鸡体内后血浆钙浓度的升高来测量类似甲状旁腺激素的生物活性。2. 对甲状旁腺功能减退患者、正常志愿者、原发性甲状旁腺功能亢进患者手术前后以及继发性甲状旁腺功能亢进患者的尿液进行了检测。3. 在原发性和继发性甲状旁腺功能亢进中，生物活性显著高于正常受试者的尿液，而正常受试者尿液的生物活性又显著高于甲状旁腺功能减退患者尿液的活性。手术切除甲状旁腺腺瘤后，这种生物活性降低。4. 胰蛋白酶消化后活性降低表明高钙物质具有肽的性质。