Lane B, Carroll B A, Pedley T A
Neurology. 1978 Jun;28(6):534-44. doi: 10.1212/wnl.28.6.534.
Computerized tomographic scans were performed on 31 patients with primary diseases of the white matter. Among 18 patients with multiple sclerosis, acute lesions were visualized in five, all with symptomatic cerebral hemisphere disease. Characteristic white matter lesions were also demonstrated in adrenoleukodystrophy, spongiform encephalopathy, progressive multifocal leukoencephalopathy, disseminated necrotizing leukoencephalopathy, and an undiagnosed leukoencephalopathy associated with malignancy. Besides identifying white matter abnormalities, the CT scan patterns were often specific enough to help distinguish among the various etiologic possibilities for the abnormalities. Useful diagnostic characteristics included the anatomic distribution of lesions, mass effect, atrophic changes, and enhancement after contrast infusion.
对31例患有白质原发性疾病的患者进行了计算机断层扫描。在18例多发性硬化症患者中，5例可见急性病变，均伴有有症状的大脑半球疾病。肾上腺脑白质营养不良、海绵状脑病、进行性多灶性白质脑病、播散性坏死性白质脑病以及一种与恶性肿瘤相关的未确诊白质脑病中也显示出特征性的白质病变。除了识别白质异常外，CT扫描模式通常具有足够的特异性，有助于区分异常的各种病因可能性。有用的诊断特征包括病变的解剖分布、占位效应、萎缩性改变以及造影剂注入后的强化情况。
