Pinnell S R, Martin G R, Miller E J
Science. 1968 Aug 2;161(3840):475-6. doi: 10.1126/science.161.3840.475.
Administration of D-penicillamine and lathyrogens such as beta-amino-propionitrile to animals markedly alters connective tissue by preventing the normal cross-linkage of elastin and collagen. It had been shown that beta-aminopropionitrile blocks the cross-linkage of elastin and collagen by preventing the initial step in cross-linkage: the conversion of lysine in peptide linkage to alpha-amino adipic-delta-semialdehyde. We show that penicillamine acts after the initial step, causing the accumulation of an elastin rich in alpha-amino adipic-delta-semialdehyde.
给动物注射D-青霉胺和诸如β-氨基丙腈之类的致痹胺会通过阻止弹性蛋白和胶原蛋白的正常交联而显著改变结缔组织。已经表明，β-氨基丙腈通过阻止交联的起始步骤——肽键中的赖氨酸转化为α-氨基己二酸-δ-半醛，来阻断弹性蛋白和胶原蛋白的交联。我们发现，青霉胺在起始步骤之后起作用，导致富含α-氨基己二酸-δ-半醛的弹性蛋白积累。
