Henry C, Jerne N K
J Exp Med. 1968 Jul 1;128(1):133-52. doi: 10.1084/jem.128.1.133.
Prior to sheep red cells (SRC) mice were given 7S or 19S anti-SRC antibodies or mixtures of both. All 7S preparations suppressed the immune response. All 19S preparations enhanced the primary response, as measured by an up to 15-fold increase in the number of PFC per spleen. Results obtained with mixtures showed that 7S and 19S antibodies are competitive in their effect. The kinetics of the appearance of PFC in the mouse spleen after injection of SRC suggest that the depressive effect of 7S antibody simulates a reduction in SRC dose, whereas the enhancing effect of 19S antibody appears as a temporary increase in the rate at which PFC appear. Antibodies from one animal species are quite effective in another species.
在注射绵羊红细胞（SRC）之前，给小鼠注射7S或19S抗SRC抗体或两者的混合物。所有7S制剂均抑制免疫反应。所有19S制剂均增强初次反应，以每脾脏中PFC数量增加多达15倍来衡量。混合物的实验结果表明，7S和19S抗体在作用上具有竞争性。注射SRC后小鼠脾脏中PFC出现的动力学表明，7S抗体的抑制作用模拟了SRC剂量的减少，而19S抗体的增强作用表现为PFC出现速率的暂时增加。来自一种动物物种的抗体在另一种物种中相当有效。
