19S和7S抗原受体在初次免疫反应调节中的竞争
Competition of 19S and 7S antigen receptors in the regulation of the primary immune response.
作者信息
Henry C, Jerne N K
出版信息
J Exp Med. 1968 Jul 1;128(1):133-52. doi: 10.1084/jem.128.1.133.
Abstract
Prior to sheep red cells (SRC) mice were given 7S or 19S anti-SRC antibodies or mixtures of both. All 7S preparations suppressed the immune response. All 19S preparations enhanced the primary response, as measured by an up to 15-fold increase in the number of PFC per spleen. Results obtained with mixtures showed that 7S and 19S antibodies are competitive in their effect. The kinetics of the appearance of PFC in the mouse spleen after injection of SRC suggest that the depressive effect of 7S antibody simulates a reduction in SRC dose, whereas the enhancing effect of 19S antibody appears as a temporary increase in the rate at which PFC appear. Antibodies from one animal species are quite effective in another species.
摘要
在注射绵羊红细胞（SRC）之前，给小鼠注射7S或19S抗SRC抗体或两者的混合物。所有7S制剂均抑制免疫反应。所有19S制剂均增强初次反应，以每脾脏中PFC数量增加多达15倍来衡量。混合物的实验结果表明，7S和19S抗体在作用上具有竞争性。注射SRC后小鼠脾脏中PFC出现的动力学表明，7S抗体的抑制作用模拟了SRC剂量的减少，而19S抗体的增强作用表现为PFC出现速率的暂时增加。来自一种动物物种的抗体在另一种物种中相当有效。
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本文引用的文献
1
THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION.抗体形成的自然选择理论。
Proc Natl Acad Sci U S A. 1955 Nov 15;41(11):849-57. doi: 10.1073/pnas.41.11.849.
2
ANTIBODY SYNTHESIS AT THE CELLULAR LEVEL. ANTIBODY-INDUCED SUPPRESSION OF 19S AND 7S ANTIBODY RESPONSE.细胞水平的抗体合成。抗体对19S和7S抗体反应的抑制作用。
J Exp Med. 1965 Jun 1;121(6):969-89. doi: 10.1084/jem.121.6.969.
3
STUDIES ON RABBIT LYMPHOCYTES IN VITRO. I. STIMULATION OF BLAST TRANSFORMATION WITH AN ANTIALLOTYPE SERUM.家兔淋巴细胞的体外研究。I. 用抗独特型血清刺激母细胞转化
J Exp Med. 1965 Aug 1;122(2):423-40. doi: 10.1084/jem.122.2.423.
4
HOMEOSTASIS OF ANTIBODY FORMATION IN THE ADULT RAT.成年大鼠抗体形成的稳态
J Exp Med. 1964 Dec 1;120(6):987-1005. doi: 10.1084/jem.120.6.987.
5
THE IMMUNOGLOBULINS OF MICE. I. FOUR MAJOR CLASSES OF IMMUNOGLOBULINS: 7S GAMMA-2-, 7S GAMMA-1-, GAMMA-1A (BETA-2A)-, AND 18S GAMMA-1M-GLOBULINS.小鼠的免疫球蛋白。I. 免疫球蛋白的四大类：7Sγ-2-、7Sγ-1-、γ-1A（β-2A）-和18Sγ-1M-球蛋白。
J Exp Med. 1964 Aug 1;120(2):223-42. doi: 10.1084/jem.120.2.223.
6
IMMUNE TOLERANCE AND AN EXTRACELLULAR REGULATORY ROLE FOR BIVALENT ANTIBODY.双价抗体的免疫耐受及细胞外调节作用
Nature. 1964 May 16;202:677-82. doi: 10.1038/202677a0.
7
SPECIFIC INHIBITION OF ANTIBODY FORMATION BY PASSIVELY ADMINISTERED 19S AND 7S ANTIBODY.被动给予19S和7S抗体对抗体形成的特异性抑制作用
Science. 1964 Oct 2;146(3640):67-9. doi: 10.1126/science.146.3640.67.
8
INHIBITION OF 19S ANTIBODY SYNTHESIS BY 7S ANTIBODY.7S抗体对19S抗体合成的抑制作用。
Science. 1964 Jul 24;145(3630):395-7. doi: 10.1126/science.145.3630.395.
9
STUDIES ON THE REACTION BETWEEN THE BLOOD-GROUP ANTIBODY ANTI-D AND ERYTHROCYTES.血型抗体抗-D与红细胞之间反应的研究
Biochem J. 1963 Sep;88(3):435-40. doi: 10.1042/bj0880435.
10
Further experimental studies on the prevention of Rh haemolytic disease.关于预防Rh溶血病的进一步实验研究。
Br Med J. 1963 Apr 13;1(5336):979-84. doi: 10.1136/bmj.1.5336.979.
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