[慢性吗啡给药对大鼠“奖赏”系统的影响]
[Effect of chronic morphine administration on the "reward" system in rats].
作者信息
Evartau E E
出版信息
Farmakol Toksikol. 1978 May-Jun;41(3):270-4.
PMID:566217
Abstract
The influence of morphine on lateral hypothalamic self-stimulation in rats was studied, The drug was injected in stepwise increasing doses from 20 to 60 and 120 mg/kg per injection. A total of 30 injections were performed in 15 days. Initial doses of every new drug injection period exerted predominantly a suppressive action upon self-stimulation, while additional injections resulted in a stable and clearcut activation of the central mechanisms mediating "rewards".
摘要
研究了吗啡对大鼠下丘脑外侧自我刺激行为的影响。每次注射时，药物剂量按20、60和120mg/kg逐步递增。15天内共注射30次。每个新药注射阶段的初始剂量主要对自我刺激行为起抑制作用，而后续注射则导致介导“奖赏”的中枢机制出现稳定且明显的激活。
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