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吗啡降低自我刺激阈值：长期给药时无耐受性。

Morphine lowering of self-stimulation thresholds: lack of tolerance with long-term administration.

作者信息

Esposito R, Kornetsky C

出版信息

Science. 1977 Jan 14;195(4274):189-91. doi: 10.1126/science.831268.

DOI:10.1126/science.831268
PMID:831268
Abstract

Rats were given increasing amounts of morphine over a period of weeks in order to achieve tolerance. Doses of the drug which initially reduced the threshold for self-stimulation behavior continued to do so after long-term administration. These results demonstrate a persistent central effect of morphine which may be related to the opiate "high."

摘要

在数周时间内，给大鼠逐渐增加吗啡剂量以使其产生耐受性。最初能降低自我刺激行为阈值的药物剂量，在长期给药后仍能继续降低该阈值。这些结果表明吗啡具有持续的中枢效应，这可能与阿片类药物的“快感”有关。

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Tolerance of the facilitatory effect of morphine on self-stimulation of the medial forebrain bundle in rats.
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[Effect of chronic morphine administration on the "reward" system in rats].[慢性吗啡给药对大鼠“奖赏”系统的影响]
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