Sarna S, Kaprio J, Sistonen P, Koskenvuo M
Hum Hered. 1978;28(4):241-54. doi: 10.1159/000152964.
A deterministic questionnaire method for zygosity determination is developed for use in epidemiological studies of adult twins. It is based on the answers of both members of a twin pair to two questions on similarity and confusion in childhood. The algorithm of the method is used to determine the zygosity status of a twin pair at two different levels of certainty. The validity of the method is tested by making blood marker determinations of 11 polymorphic marker systems fro a random sample of 104 twin pairs. The agreement between questionnaire and blood marker diagnosis was 100%, but the stricter level of certainty left 8.7% in the nonclassified group. The genetical representativeness of the sample is tested by the allele distribution of the markers as compared to the Finnish population data as well as by the distribution of the number of intra-pair differences in blood markers.
一种用于确定成年双胞胎合子性的确定性问卷方法被开发出来，用于成年双胞胎的流行病学研究。它基于双胞胎对中双方对关于童年相似性和混淆性的两个问题的回答。该方法的算法用于在两个不同的确定水平上确定双胞胎对的合子性状态。通过对104对双胞胎的随机样本进行11个多态性标记系统的血液标记测定，对该方法的有效性进行了测试。问卷诊断与血液标记诊断之间的一致性为100%，但更严格的确定水平使未分类组中仍有8.7%。通过将标记的等位基因分布与芬兰人群数据进行比较，以及通过血液标记中配对内差异数量的分布，对样本的遗传代表性进行了测试。
