Salsbury A J, Brozovich M
Br Med J. 1968 Aug 10;3(5614):352-5. doi: 10.1136/bmj.3.5614.352.
Clinical experience with a 4.3% solution of plasma protein treated to render it free of the agent of serum hepatitis is satisfactory. Sixty-seven transfusions of 400 ml. of the commercial preparation were given to 33 patients (25 with acute blood loss, 4 with severe burns, and 4 with hypoproteinaemia secondary to hepatic or renal disease).The solution was clinically as effective as reconstituted dried plasma in expanding plasma volume and in replacing serum protein lost in burns. Adverse effects were mild pyrexial reactions in one case and facial flushing in another. No cases of serum hepatitis occurred.The solution is available for immediate use, it can be kept at room temperature, and, as it does not cause rouleaux formation, it can be given before blood is taken for grouping and cross-matching.
对经处理以去除血清性肝炎病原体的4.3%血浆蛋白溶液的临床应用经验令人满意。向33例患者输注了67次400毫升的该商业制剂（25例急性失血患者、4例严重烧伤患者和4例继发于肝脏或肾脏疾病的低蛋白血症患者）。该溶液在扩充血浆容量和补充烧伤所致血清蛋白丢失方面，临床效果与冻干血浆复溶制剂相同。不良反应包括1例轻度发热反应和另1例面部潮红。未发生血清性肝炎病例。该溶液可立即使用，能在室温下保存，且由于不会引起红细胞缗钱状形成，可在采血进行血型鉴定和交叉配血之前输注。
