一种用于估算小鼠组织中喜树碱内酯浓度的微生物测定法。
A microbiological assay for estimating concentrations of camptothecin lactone in mouse tissues.
作者信息
Hunt D E, Pittillo R F
出版信息
Appl Microbiol. 1968 Jun;16(6):867-70. doi: 10.1128/am.16.6.867-870.1968.
The marked sensitivity of the yeast Hansenula wingei NRRL Y-2340 strain 5 to a new antineoplastic alkaloid served as the basis for a logarithmic-ratio microbiological assay which has been developed for the estimation of concentrations of camptothecin lactone (or cytotoxic equivalents) in tissues of mice. The utility of this assay has been demonstrated by presenting data which show the concentrations of camptothecin lactone (or cytotoxic equivalents) detected in various tissues of mice at intervals following intraperitoneal injection of a 1 or 0.5 ld(10) dose of this drug.
酵母汉逊酵母NRRL Y - 2340菌株5对一种新型抗肿瘤生物碱具有显著敏感性，以此为基础开发了一种对数比率微生物测定法，用于估算小鼠组织中喜树碱内酯（或细胞毒性等效物）的浓度。通过呈现的数据证明了该测定法的实用性，这些数据显示了在腹腔注射1或0.5 ld(10)剂量的该药物后，在不同时间间隔小鼠各组织中检测到的喜树碱内酯（或细胞毒性等效物）的浓度。
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