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1
Factors controlling the washout of the interstitial space of the isolated, perfused rat heart.控制离体灌注大鼠心脏间质空间洗脱的因素。
J Physiol. 1968 Jun;196(3):747-59. doi: 10.1113/jphysiol.1968.sp008534.
2
Removal of an insulin inhibitor from the rat heart by perfusion.通过灌注去除大鼠心脏中的胰岛素抑制剂。
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Physiological pharmacokinetics of solutes in the isolated perfused rat hindlimb: characterization of the physiology with changing perfusate flow, protein content, and temperature using statistical moment analysis.溶质在离体灌注大鼠后肢中的生理药代动力学：利用统计矩分析表征随着灌注液流量、蛋白质含量和温度变化的生理学特性。
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The effect of loading and extraction temperatures, composition of medium, and molecular size on retention of extracellular space marker by mouse cerebrum slices.加载温度、提取温度、培养基成分和分子大小对小鼠大脑切片细胞外空间标志物保留率的影响。
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1
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2
The inhibition by (+/-)-propranolol of the positive inotropic effects of (+/-)-isoprenaline and (-)-noradrenaline. Competitive antagonism and saturable uptake.（±）-普萘洛尔对（±）-异丙肾上腺素和（-）-去甲肾上腺素正性肌力作用的抑制。竞争性拮抗和可饱和摄取。
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3
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Saturation kinetics of the adrenergic neurone uptake system in the perfused rabbit heart. A new method for determination of initial rates of amine uptake.灌注兔心脏中肾上腺素能神经元摄取系统的饱和动力学。一种测定胺摄取初始速率的新方法。
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本文引用的文献

1
Action of calcium ions on the frog's heart.钙离子对青蛙心脏的作用。
J Physiol. 1928 Dec 20;66(4):346-55. doi: 10.1113/jphysiol.1928.sp002532.
2
The action of insulin on the aseptically perfused heart.胰岛素对无菌灌注心脏的作用。
J Physiol. 1927 Aug 8;63(3):242-8. doi: 10.1113/jphysiol.1927.sp002400.
3
Contributions to the physiology of the isolated heart: The consumption of dextrose by mammalian cardiac muscle.对离体心脏生理学的贡献：哺乳动物心肌对葡萄糖的消耗。
J Physiol. 1907 Dec 31;36(4-5):205-20. doi: 10.1113/jphysiol.1907.sp001229.
4
Fructose and glucose in the blood of the foetal sheep.胎羊血液中的果糖和葡萄糖。
Biochem J. 1948;42(3):397-405. doi: 10.1042/bj0420397.
5
Studies on inflammation. II. The site of action of histamine and serotonin along the vascular tree: a topographic study.炎症研究。II. 组胺和5-羟色胺沿血管树的作用部位：一项局部解剖学研究。
J Biophys Biochem Cytol. 1961 Dec;11(3):607-26. doi: 10.1083/jcb.11.3.607.
6
Further studies of the kinetics of glucose utilization. I. A new method of data analysis.葡萄糖利用动力学的进一步研究。I. 一种新的数据分析方法。
J Clin Endocrinol Metab. 1959 Oct;19:1258-73. doi: 10.1210/jcem-19-10-1258.
7
A TOPOGRAPHICAL STUDY OF INCREASED VASCULAR PERMEABILITY IN ACUTE TURPENTINE-INDUCED PLEURISY.急性松节油诱导性胸膜炎中血管通透性增加的局部解剖学研究
J Pathol Bacteriol. 1965 Jan;89:245-54.
8
PERMEABILITY OF MAMMALIAN HEART CAPILLARIES TO SUCROSE AND INULIN.哺乳动物心脏毛细血管对蔗糖和菊粉的通透性
Am J Physiol. 1964 May;206:985-91. doi: 10.1152/ajplegacy.1964.206.5.985.
9
THE DELAYED AND PROLONGED VASCULAR LEAKAGE IN INFLAMMATION. I. TOPOGRAPHY OF THE LEAKING VESSELS AFTER THERMAL INJURY.炎症中延迟和持续的血管渗漏。I. 热损伤后渗漏血管的局部解剖学。
Am J Pathol. 1964 Aug;45(2):261-81.
10
Extravascular fluid losses in the perfused isolated rabbit heart.灌注离体兔心脏的血管外液丢失
J Physiol. 1959 Oct;148(2):393-402. doi: 10.1113/jphysiol.1959.sp006295.

控制离体灌注大鼠心脏间质空间洗脱的因素。

Factors controlling the washout of the interstitial space of the isolated, perfused rat heart.

作者信息

Young D A

出版信息

J Physiol. 1968 Jun;196(3):747-59. doi: 10.1113/jphysiol.1968.sp008534.

DOI:10.1113/jphysiol.1968.sp008534
PMID:5664240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1351775/
Abstract
  1. The time course of the washout of the extracellular markers, inulin, raffinose, sucrose and sorbitol, has been determined for the isolated rat heart perfused for 20 min with Krebs bicarbonate medium containing the marker, and washed out with marker-free perfusate.2. The filtration problem for the perfused rat heart was found to be due to omission of the gassing of the concentrated sodium bicarbonate solution with CO(2) in the preparation of the perfusate. This probably caused calcium phosphate to be precipitated. The reduced contractility of the heart was reflected in the washout of the extracellular markers.3. The logarithmic plot of the heart content of the marker against time showed two components. The slower was an exponential process, the rate of which was linearly related to the diffusion coefficient for the various markers.4. The faster component was absent in the quiescent heart, and in the beating heart its contribution to the washout of the interstitial space was related to the strength of contraction.5. Similar washout curves were obtained for Evans Blue-albumin conjugate, which readily penetrates the interstitial space of the isolated rat heart.6. It is suggested that the two components of efflux are a diffusion process limited by perfusate flow, and bulk movements of fluid.
摘要

  1. 已测定了细胞外标记物菊粉、棉子糖、蔗糖和山梨醇的洗脱时间进程，采用含有标记物的 Krebs 碳酸氢盐培养基灌注离体大鼠心脏 20 分钟，然后用无标记物的灌注液进行洗脱。

  2. 发现灌注大鼠心脏的滤过问题是由于在制备灌注液时未对浓碳酸氢钠溶液进行 CO₂ 通气。这可能导致磷酸钙沉淀。心脏收缩力的降低反映在细胞外标记物的洗脱上。

  3. 标记物在心脏中的含量对时间的对数图显示有两个成分。较慢的是一个指数过程，其速率与各种标记物的扩散系数呈线性相关。

  4. 静止心脏中不存在较快的成分，而在跳动的心脏中，其对间质空间洗脱的贡献与收缩强度有关。

  5. 对于伊文思蓝 - 白蛋白复合物也获得了类似的洗脱曲线，该复合物很容易穿透离体大鼠心脏的间质空间。

  6. 有人提出，流出的两个成分是受灌注液流动限制的扩散过程和液体的大量运动。