Lerner L J, Oldani C, Vitale A
Prostaglandins. 1978 Mar;15(3):525-31. doi: 10.1016/0090-6980(78)90136-3.
The effects of 2(3-ethoxyphenyl)-5,6-dihydro-s-triazole-[5,1-a]isoquinoline (L-11204 or DL 204 IT and PGE2 on ovulation and ova transport were studied. DI 204 IT was administered in doses of 0.2-25 mg/kg s.c. on the day of estrus. A smal reduction in ovulating follicles was observed 96 hours later, but only at the 5 mg/kg dose level. At all dose levels, however, DL 204 IT caused a dose-related reduction in the number of ova in the oviducts. PGE2 at a total dose of 2 mg/animal s.c., administered in 4 divided doses over the second and third day of the cycle did not affect ovulation or ova transport. PGE2 plus DL 204 IT (5 mg/kg), however, completely blocked ovulation in all but one animal. That animal had one ovulated follicle and a single ova was recovered from its oviduct.
研究了2-(3-乙氧基苯基)-5,6-二氢-s-三唑-[5,1-a]异喹啉（L-11204或DL 204 IT）和前列腺素E2（PGE2）对排卵和卵子运输的影响。在发情当天，以0.2-25mg/kg的剂量皮下注射DL 204 IT。96小时后观察到排卵卵泡略有减少，但仅在5mg/kg剂量水平。然而，在所有剂量水平下，DL 204 IT都会导致输卵管中卵子数量呈剂量相关减少。在周期的第二天和第三天，以2mg/动物的总剂量皮下注射PGE2，分4次给药，对排卵或卵子运输没有影响。然而，PGE2加DL 204 IT（5mg/kg）除一只动物外完全阻断了所有动物的排卵。那只动物有一个排卵卵泡，从其输卵管中回收了一个卵子。
