Lerner L J, Oldani C, Vitale A
Prostaglandins Med. 1981 Apr;6(4):369-74. doi: 10.1016/0161-4630(81)90068-9.
The compound 2(3-ethoxyphenyl)-5, 6-dihydro-s-triazole- [5, 1-2] isoquinoline (DL-204-IT or L-11204) inhibited PMS-induced superovulation and reduced the number of recoverable ova in the oviducts of hamsters. PGE2 non-significantly reduced the number of ova shed but significantly decreased the number of oviductal ova. DL-204-IT was more potent than PGE2 for these effects. Administration of both compounds resulted in a complete block of ovulation. Inhibition of prostaglandin metabolism by DL-204-IT may be the cause for these effects, but no direct evidence is presently available.
化合物2(3-乙氧基苯基)-5,6-二氢-s-三唑-[5,1-2]异喹啉（DL-204-IT或L-11204）抑制了孕马血清促性腺激素诱导的超排卵，并减少了仓鼠输卵管中可回收卵子的数量。前列腺素E2（PGE2）对排出卵子的数量减少作用不显著，但显著降低了输卵管内卵子的数量。对于这些作用，DL-204-IT比PGE2更有效。两种化合物给药均导致排卵完全受阻。DL-204-IT对前列腺素代谢的抑制作用可能是这些作用的原因，但目前尚无直接证据。
