Wiener S G, Levine S
Dev Psychobiol. 1978 Jul;11(4):335-52. doi: 10.1002/dev.420110407.
The preweaning development of the pituitary-adrenal system was investigated in perinatally malnourished rodents. Malnourished pups that were routinely handled displayed an earlier plasma corticosterone stress response to electric shock and an accelerated development of feedback inhibition of the stress response by exogenously elevated steroid levels. Although malnourished pups displayed elevated basal corticosterone levels compared to well-fed controls, the post-stress levels were also higher in these malnourished young. Thus, the corticosterone response to stress was not impaired in malnourished pups. The influence of the early handling of malnourished young on pituitary-adrenal activity was also studied. Whereas the accelerated development of the stress response and the elevated post-shock levels were not the result of early handling, the elevated basal corticosterone levels displayed by handled malnourished pups were not present in nonhandled malnourished pups. Thus, the early non-nutritional environment interacts with malnutrition to alter the development of the pituitary-adrenal system.
对围产期营养不良的啮齿动物垂体 - 肾上腺系统的断奶前发育进行了研究。经常接受处理的营养不良幼崽对电击表现出更早的血浆皮质酮应激反应，并且外源性升高的类固醇水平对应激反应的反馈抑制作用加速发展。尽管与喂养良好的对照组相比，营养不良的幼崽基础皮质酮水平升高，但这些营养不良的幼崽应激后水平也更高。因此，营养不良的幼崽对压力的皮质酮反应并未受损。还研究了早期处理营养不良幼崽对垂体 - 肾上腺活动的影响。虽然应激反应的加速发展和电击后升高的水平不是早期处理的结果，但接受处理的营养不良幼崽所表现出的基础皮质酮水平升高在未接受处理的营养不良幼崽中并不存在。因此，早期非营养环境与营养不良相互作用，改变了垂体 - 肾上腺系统的发育。
