脱氧皮质酮在毛花洋地黄强心苷生物合成中的作用。

The role of deoxycorticosterone in the biosynthesis of cardenolides in Digitalis lanata.

作者信息

Caspi E, Wickramasinghe J A, Lewis D O

出版信息

Biochem J. 1968 Jul;108(3):499-503. doi: 10.1042/bj1080499.

DOI:10.1042/bj1080499

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1198836/

Abstract

The role of deoxycorticosterone in the biosynthesis of digitoxigenin was investigated by the simultaneous administration of deoxy[1,2-(3)H(2)]corticosterone and [4-(14)C]progesterone to a Digitalis lanata plant. The biosynthetically formed [(3)H,(14)C]digitoxigenin and deoxy[(3)H,(14)C]corticosterone were isolated and the distribution of the two isotopes in these products was determined. The transformation of progesterone into deoxycorticosterone in vivo was established. The biosynthetic route from progesterone via deoxycorticosterone to cardenolides was found to be of little significance.

摘要

通过向毛花洋地黄植株同时施用脱氧[1,2-(3)H(2)]皮质酮和[4-(14)C]孕酮，研究了脱氧皮质酮在洋地黄毒苷元生物合成中的作用。分离出生物合成形成的[(3)H,(14)C]洋地黄毒苷元和脱氧[(3)H,(14)C]皮质酮，并测定了这两种同位素在这些产物中的分布。确定了孕酮在体内向脱氧皮质酮的转化。发现从孕酮经脱氧皮质酮到强心苷的生物合成途径意义不大。

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本文引用的文献

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