Weiner W J, Nausieda P A, Klawans H L
Neurology. 1978 Jul;28(7):734-7. doi: 10.1212/wnl.28.7.734.
Chronic administration of a levodopa-carbidopa combination, bromocriptine, or lergotrile produced alterations of essential metal concentrations in the guinea pig caudate nucleus, frontal cortex, and cerebellar hemisphere. All long-term treatment regimens resulted in significantly increased concentrations of manganese in all brain areas, and these same regimens resulted in almost universally decreased copper concentrations. Since the long-term administration of these dopamine agonists in man results in extrapyramidal dysfunction, these observations suggest that alterations of trace metal concentrations in the brain may be related to the chronic toxicity of these dopamine agonists.
长期给予左旋多巴-卡比多巴组合、溴隐亭或麦角腈会导致豚鼠尾状核、额叶皮质和小脑半球中必需金属浓度发生改变。所有长期治疗方案均导致所有脑区的锰浓度显著升高，且相同方案几乎普遍导致铜浓度降低。由于在人类中长期给予这些多巴胺激动剂会导致锥体外系功能障碍，这些观察结果表明，脑中痕量金属浓度的改变可能与这些多巴胺激动剂的慢性毒性有关。
