Ahmed F, Sumalnop V, Spain D M, Tobin M S
Arch Intern Med. 1978 Aug;138(8):1292-3.
Penicillamine therapy was associated with the development of thrombohemolytic thrombocytopenic purpura (TTP) in a 23-year-old woman. The immunological and hematological toxicity of penicillamine, as well as the occurrence of TTP with parent penicillin compounds, indicates a probable etiological role of this drug.
青霉胺治疗与一名23岁女性血栓性血小板减少性紫癜(TTP)的发生有关。青霉胺的免疫和血液学毒性,以及母体青霉素化合物引发TTP的情况,表明该药物可能具有病因学作用。