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Inhibition of coenzyme Q systems by chloroquine and other antimalarials.

作者信息

Skelton F S, Pardini R S, Heidker J C, Folkers K

出版信息

J Am Chem Soc. 1968 Sep 11;90(19):5334-6. doi: 10.1021/ja01021a084.

DOI:10.1021/ja01021a084
PMID:5670801
Abstract
摘要

相似文献

1
Inhibition of coenzyme Q systems by chloroquine and other antimalarials.氯喹及其他抗疟药对辅酶Q系统的抑制作用。
J Am Chem Soc. 1968 Sep 11;90(19):5334-6. doi: 10.1021/ja01021a084.
2
Synthesis of new 2-alkylamino-1,4-naphthoquinones as inhibitors of coenzyme Q and as antimalarials.新型2-烷基氨基-1,4-萘醌作为辅酶Q抑制剂和抗疟药的合成
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Antimetabolites of coenzyme Q. Their potential application as antimalarials.辅酶Q的抗代谢物。它们作为抗疟药的潜在应用。
Angew Chem Int Ed Engl. 1974 Sep;13(9):559-69. doi: 10.1002/anie.197405591.
4
Antimetabolites of coenzyme Q. 20. Synthesis of new alkyl-5,8-quinoxalinequinones as potential inhibitors of coenzyme Q and as antimalarial drugs.辅酶Q的抗代谢物。20. 新型烷基-5,8-喹喔啉醌的合成，作为辅酶Q的潜在抑制剂和抗疟药物。
J Med Chem. 1973 Nov;16(11):1310-1. doi: 10.1021/jm00269a024.
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New substituted 2,3-dimethoxy-1,4-benzoquinones as inhibitors of coenzyme Q systems.新型取代的2,3 - 二甲氧基 - 1,4 - 苯醌作为辅酶Q系统的抑制剂
J Med Chem. 1971 Jan;14(1):45-8. doi: 10.1021/jm00283a012.
6
Synthesis of new 5,8-quinolinequinones as inhibitors of coenzymes Q and as antimalarials.新型5,8-喹啉醌作为辅酶Q抑制剂和抗疟药的合成。
J Med Chem. 1971 Nov;14(11):1029-33. doi: 10.1021/jm00293a003.
7
Synthesis of new alkylamino- and alkylaminomethyl-5,8-quinolinequinones as inhibitors of coenzyme Q and as antimalarials.新型烷基氨基和烷基氨基甲基-5,8-喹啉醌的合成：作为辅酶Q抑制剂和抗疟药物
J Med Chem. 1972 Jan;15(1):34-6. doi: 10.1021/jm00271a009.
8
New hydroxyquinones, apparent inhibitors of coenzyme Q enzyme systems.新型羟基醌类化合物，可能是辅酶Q酶系统的抑制剂。
J Am Chem Soc. 1968 Jun 19;90(13):3572-4. doi: 10.1021/ja01015a054.
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Antimalarial quinones for prophylaxis based on a rationale of inhibition of electron transfer in Plasmodium.基于抑制疟原虫电子传递原理的用于预防的抗疟醌类药物。
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Coenzyme Q. CXXII. Identification of ubiquinone-8 biosynthesized by Plasmodium knowlesi, P. cynomolgi, and P. berghei.辅酶Q。CXXII。诺氏疟原虫、食蟹猴疟原虫和伯氏疟原虫生物合成的泛醌-8的鉴定。
J Med Chem. 1970 Jul;13(4):602-6. doi: 10.1021/jm00298a004.

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Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story.氯喹和羟氯喹治疗 COVID-19：一个永无止境的故事。
Appl Microbiol Biotechnol. 2021 Feb;105(4):1333-1343. doi: 10.1007/s00253-021-11094-4. Epub 2021 Jan 30.
2
Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome That Are Transmissible through Mosquitoes.疟原虫对甲萘醌的抗性由细胞色素中的M133I突变赋予，该突变可通过蚊子传播。
Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.00689-17. Print 2017 Aug.
3
Purification and characterization of phosphoenolpyruvate carboxylase from Plasmodium berghei.
来自伯氏疟原虫的磷酸烯醇式丙酮酸羧化酶的纯化与鉴定
J Bacteriol. 1972 Jan;109(1):385-90. doi: 10.1128/jb.109.1.385-390.1972.
4
[Biochemistry of some parasitic helminths and protozoa and the mode of action of some antiparasitic drugs].[某些寄生蠕虫和原生动物的生物化学以及某些抗寄生虫药物的作用方式]
Z Parasitenkd. 1970;34(4):271-95. doi: 10.1007/BF00260297.
5
A durohydroquinone oxidation site in the mitochondrial transport chain.
J Bioenerg. 1971 Dec;2(5):317-26. doi: 10.1007/BF01963828.
6
The effect of some cyclodiene pesticides, benzenehexachloride and toxaphene on mitochondrial electron transport.
Bull Environ Contam Toxicol. 1971 Sep-Oct;6(5):436-44. doi: 10.1007/BF01684365.
7
Requirement for coenzyme Q in plasma membrane electron transport.质膜电子传递中辅酶Q的需求
Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11126-30. doi: 10.1073/pnas.89.23.11126.
8
Inhibition of precursor incorporation into nucleic acids of mammalian tissues by antimalarial aminoquinolines.抗疟氨基喹啉对哺乳动物组织中核酸前体掺入的抑制作用。
Br J Pharmacol. 1978 Feb;62(2):159-64. doi: 10.1111/j.1476-5381.1978.tb08440.x.